Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.
| Version: | 0.1.0 |
| Depends: | R (≥ 3.6) |
| Imports: | checkmate, furrr, future, mstate, parallelly, stats, survival |
| Suggests: | coxphw, knitr, mvna, prodlim, rmarkdown, rpact, testthat (≥ 3.0.0) |
| Published: | 2023-12-11 |
| DOI: | 10.32614/CRAN.package.simIDM |
| Author: | Alexandra Erdmann [aut, cre], Kaspar Rufibach [aut], Holger Löwe [aut], Daniel Sabanés Bové [aut], F. Hoffmann-La Roche AG [cph, fnd], University of Ulm [cph, fnd] |
| Maintainer: | Alexandra Erdmann <alexandra.erdmann at uni-ulm.de> |
| BugReports: | https://github.com/insightsengineering/simIDM/issues |
| License: | Apache License 2.0 |
| URL: | https://github.com/insightsengineering/simIDM/ |
| NeedsCompilation: | no |
| Language: | en-US |
| Materials: | NEWS |
| CRAN checks: | simIDM results |
| Reference manual: | simIDM.pdf |
| Vignettes: |
Correlation between PFS and OS Piecewise Constant Hazards Calculations Getting Started Power and Type I Error Calculations |
| Package source: | simIDM_0.1.0.tar.gz |
| Windows binaries: | r-devel: simIDM_0.1.0.zip, r-release: simIDM_0.1.0.zip, r-oldrel: simIDM_0.1.0.zip |
| macOS binaries: | r-release (arm64): simIDM_0.1.0.tgz, r-oldrel (arm64): simIDM_0.1.0.tgz, r-release (x86_64): simIDM_0.1.0.tgz, r-oldrel (x86_64): simIDM_0.1.0.tgz |
| Old sources: | simIDM archive |
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