cobenrich: Using Multiple Continuous Biomarkers for Patient Enrichment in Two-Stage Clinical Designs

Enrichment strategies play a critical role in modern clinical trial design, especially as precision medicine advances the focus on patient-specific efficacy. Recent developments in enrichment design have introduced biomarker randomness and accounted for the correlation structure between treatment effect and biomarker, resulting in a two-stage threshold enrichment design. We propose novel two-stage enrichment designs capable of handling two or more continuous biomarkers. See Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report.

Version:	1.0.1
Depends:	R (≥ 4.2.0)
Imports:	tmvtnorm (≥ 1.2), stats (≥ 4.0.0)
Published:	2025-04-15
DOI:	10.32614/CRAN.package.cobenrich
Author:	Jiangtao Gou [aut, cre], Fengqing (Zoe) Zhang [aut]
Maintainer:	Jiangtao Gou <gouRpackage at gmail.com>
License:	GPL-3
NeedsCompilation:	no
CRAN checks:	cobenrich results

Documentation:

Reference manual:

cobenrich.html , cobenrich.pdf

Downloads:

Package source:	cobenrich_1.0.1.tar.gz
Windows binaries:	r-devel: cobenrich_1.0.1.zip, r-release: cobenrich_1.0.1.zip, r-oldrel: cobenrich_1.0.1.zip
macOS binaries:	r-release (arm64): cobenrich_1.0.1.tgz, r-oldrel (arm64): cobenrich_1.0.1.tgz, r-release (x86_64): cobenrich_1.0.1.tgz, r-oldrel (x86_64): cobenrich_1.0.1.tgz

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