SATS: Signature Analyzer for Targeted Sequencing (SATS)

Performs mutational signature analysis for targeted sequenced tumors. Unlike the canonical analysis of mutational signatures, SATS factorizes the mutation counts matrix into a panel context matrix (measuring the size of the targeted sequenced genome for each tumor in the unit of million base pairs (Mb)), a signature profile matrix, and a signature activity matrix. SATS also calculates the expected number of mutations attributed by a signature, namely signature expectancy, for each targeted sequenced tumor. For more details see Lee et al. (2024) <doi:10.1101/2023.05.18.23290188>.

Version:	1.0.4
Depends:	R (≥ 4.1.0)
Imports:	stats, glmnet, GenomicRanges, IRanges, Biostrings, dplyr, BSgenome.Hsapiens.UCSC.hg19
Suggests:	testthat
Published:	2025-07-05
DOI:	10.32614/CRAN.package.SATS
Author:	DongHyuk Lee [aut], Bin Zhu [aut], Bill Wheeler [cre]
Maintainer:	Bill Wheeler <wheelerb at imsweb.com>
License:	GPL-2
NeedsCompilation:	yes
CRAN checks:	SATS results

Documentation:

Reference manual:

SATS.pdf

Downloads:

Package source:	SATS_1.0.4.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available

Linking:

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