Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials

Documentation for package ‘bcrm’ version 0.5.4

bcrm-package	Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials
bcrm	Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials
find.x	Obtain samples from the maximum tolerated dose (MTD) distribution.
getprior	Samples from the specified prior distribution.
plot.bcrm	Plot the estimated dose-toxicity curve
plot.bcrm.sim	Plot the operating characteristics from the simulated trials
plot.threep3	Plot the operating characteristics from a standard 3+3 trial
Posterior.BRugs	Returns samples from the posterior distributions of each model parameter using OpenBUGS.
Posterior.exact	Returns posterior mean parameter value and summaries of distributions for probability of DLT at each dose level
Posterior.exact.sim	Returns posterior mean parameter value and summaries of distributions for probability of DLT at each dose level
Posterior.R2WinBUGS	Returns samples from the posterior distributions of each model parameter using WinBUGS
Posterior.rjags	Returns samples from the posterior distributions of each model parameter using JAGS.
print.bcrm	Print information regarding a trial conducted using the Bayesian continuous reassessment method
print.bcrm.sim	Print information regarding a trial conducted using the Bayesian continuous reassessment method
print.threep3	Print information regarding the operating characteristics of a standard 3+3 design
threep3	Calculate all possible trial pathways for the standard 3+3 design, together with their probability of occurring