apply_poppk | Apply a population PK model to a data frame |
apply_targetfn | Apply target function to a PK-PD model |
assign_pars | Set default PK parameter values Set default PK parameter values for a pkmod object. |
bayes_control | Bayesian closed-loop control |
cl_targets | Closed-loop targets |
cl_updates | Closed-loop updates |
combine_sim | Combine simulation outputs |
create_intvl | dosing schedule Create dosing schedule |
eleveld_pd | Eleveld et al. pharmacodynamic data |
eleveld_pk | Eleveld et al. pharmacokinetic data |
eleveld_poppk | Eleveld population PK model |
eleveld_vcov | Generate variance-covariance matrix for Eleveld PK-PD model |
elvdlpars | Get logged parameters updated in Eleveld model |
emax | Emax function |
emax_eleveld | Emax function for Eleveld (2018) model. |
format_pars | Format parameters for use in Rcpp functions Order parameters for 1-4 compartment models to be used in Rcpp functions in predict_pkmod method. |
gen_data | Function to simulate data from a specified PK or PK-PD model with a specified infusion schedule. |
gen_eleveld_pd_pars | Eleveld model PD parameters |
gen_eleveld_pk_pars | Eleveld model PK parameters |
gen_eleveld_pk_pars_nonmem | Generate Eleveld model PK parameters |
inv_emax | Inverse Emax function |
inv_emax_eleveld | Inverse Emax function |
log_likelihood | Evaluate log-likelihood |
log_posterior_neg | Function to evaluate the negative log posterior given a set of logged parameter values and observed BIS values. |
log_prior | Calculate logged prior value |
marsh_poppk | ---- Population PK and PK-PD functions -- ---- Marsh population PK model. |
pal | Color palate for tci plotting functions |
pkmod1cpt | One compartment IV infusion with first-order elimination. |
pkmod2cpt | Two compartment IV infusion with first-order elimination. |
pkmod3cpt | Three compartment IV infusion with first-order elimination. |
pkmod3cptm | Solution to three-compartment IV model with effect-site |
pk_basic_solution_3cpt_metab | Solution to three-compartment IV model |
pk_solution_3cpt_metab | Iterate solution to three-compartment model |
pk_solution_3cpt_metab_singleinf | Single infusion 3-compartment PK solution |
plot.bayessim | Plot object with class 'pkmod' |
plot.datasim | Plot object with class 'pkmod' |
plot.pdmod | Plot object with class 'pkmod' |
plot.pkmod | Plot object with class 'pkmod' |
plot.tciinf | Plot object with class 'pkmod' |
predict_pkmod | Predict concentrations from a pkmod object - can be a user defined function |
predict_pkmod_Rcpp | Predict concentrations from a pkmod object using Rcpp implementations |
restrict_sigmoid | Restrict target sigmoid values |
schnider_poppk | Schnider population PK model |
seqby | Sequence including bounds |
sigmoid_targetfn | Sigmoid target function |
tail_vec | Extract last element or column |
tci | Apply TCI algorithm |
tci_comb | Effect-site TCI algorithm with plasma targeting within small range of target |
tci_documentation | tci_documentation |
tci_effect | TCI algorithm for effect-site targeting |
tci_pd | Function to extend TCI grid to a set of PD targets |
tci_plasma | TCI algorithm for plasma targeting |