Target Controlled Infusion (TCI)


[Up] [Top]

Documentation for package ‘tci’ version 0.1.2

Help Pages

apply_poppk Apply a population PK model to a data frame
apply_targetfn Apply target function to a PK-PD model
assign_pars Set default PK parameter values Set default PK parameter values for a pkmod object.
bayes_control Bayesian closed-loop control
cl_targets Closed-loop targets
cl_updates Closed-loop updates
combine_sim Combine simulation outputs
create_intvl dosing schedule Create dosing schedule
eleveld_pd Eleveld et al. pharmacodynamic data
eleveld_pk Eleveld et al. pharmacokinetic data
eleveld_poppk Eleveld population PK model
eleveld_vcov Generate variance-covariance matrix for Eleveld PK-PD model
elvdlpars Get logged parameters updated in Eleveld model
emax Emax function
emax_eleveld Emax function for Eleveld (2018) model.
format_pars Format parameters for use in Rcpp functions Order parameters for 1-4 compartment models to be used in Rcpp functions in predict_pkmod method.
gen_data Function to simulate data from a specified PK or PK-PD model with a specified infusion schedule.
gen_eleveld_pd_pars Eleveld model PD parameters
gen_eleveld_pk_pars Eleveld model PK parameters
gen_eleveld_pk_pars_nonmem Generate Eleveld model PK parameters
inv_emax Inverse Emax function
inv_emax_eleveld Inverse Emax function
log_likelihood Evaluate log-likelihood
log_posterior_neg Function to evaluate the negative log posterior given a set of logged parameter values and observed BIS values.
log_prior Calculate logged prior value
marsh_poppk ---- Population PK and PK-PD functions -- ---- Marsh population PK model.
pal Color palate for tci plotting functions
pkmod1cpt One compartment IV infusion with first-order elimination.
pkmod2cpt Two compartment IV infusion with first-order elimination.
pkmod3cpt Three compartment IV infusion with first-order elimination.
pkmod3cptm Solution to three-compartment IV model with effect-site
pk_basic_solution_3cpt_metab Solution to three-compartment IV model
pk_solution_3cpt_metab Iterate solution to three-compartment model
pk_solution_3cpt_metab_singleinf Single infusion 3-compartment PK solution
plot.bayessim Plot object with class 'pkmod'
plot.datasim Plot object with class 'pkmod'
plot.pdmod Plot object with class 'pkmod'
plot.pkmod Plot object with class 'pkmod'
plot.tciinf Plot object with class 'pkmod'
predict_pkmod Predict concentrations from a pkmod object - can be a user defined function
predict_pkmod_Rcpp Predict concentrations from a pkmod object using Rcpp implementations
restrict_sigmoid Restrict target sigmoid values
schnider_poppk Schnider population PK model
seqby Sequence including bounds
sigmoid_targetfn Sigmoid target function
tail_vec Extract last element or column
tci Apply TCI algorithm
tci_comb Effect-site TCI algorithm with plasma targeting within small range of target
tci_documentation tci_documentation
tci_effect TCI algorithm for effect-site targeting
tci_pd Function to extend TCI grid to a set of PD targets
tci_plasma TCI algorithm for plasma targeting